Understanding IVF with PGT (Preimplantation Genetic Testing)
How Genetic Testing of Embryos Can Improve Your Success in the Philippines
Advanced IVF technology now allows us to select the healthiest embryos before transfer. Discover how PGT can increase pregnancy rates and reduce miscarriage risk.
At Alpha IVF Manila Inc., we’re proud to offer Preimplantation Genetic Testing (PGT)—one of the most significant advancements in reproductive technology. For many couples, especially those with genetic concerns or recurrent pregnancy loss, PGT can transform their IVF journey. This comprehensive guide explains what PGT is, who benefits, and what to expect at our Manila clinics.
What is PGT? The Basics Explained Simply
Preimplantation Genetic Testing (PGT) is a procedure used during IVF to examine embryos for genetic abnormalities before they are transferred to the uterus. Think of it as a quality check that helps identify the embryos with the best chance of developing into a healthy pregnancy.
The 3 Types of PGT: Which One Is Right for You?
| Type | Full Name | What It Tests For | Best For |
| PGT-A | Aneuploidy Screening | Extra or missing chromosomes (Down syndrome, etc.) | Women over 35, recurrent miscarriage, failed IVF cycles |
| PGT-M | Monogenic/Single Gene Disorders | Specific inherited conditions (Thalassemia, Cystic Fibrosis) | Couples with known genetic disorders in family |
| PGT-SR | Structural Rearrangements | Chromosome rearrangements (translocations) | Carriers of balanced translocations |
The PGT Process: Step-by-Step at Alpha Fertility Centre
Step 1: Standard IVF Cycle
- Ovarian stimulation and egg retrieval as with conventional IVF
- Fertilization via ICSI (required for PGT to prevent sperm DNA contamination)
Step 2: Embryo Biopsy (Day 5 or 6)
- Our embryologists carefully remove 5-10 cells from the trophectoderm (future placenta) of the blastocyst
- Important: This does NOT harm the inner cell mass (future baby)
- Embryos are immediately vitrified (flash-frozen) after biopsy
Step 3: Genetic Analysis
- Biopsied cells are sent to our partner genetics laboratory
- Analysis using advanced techniques like NGS (Next Generation Sequencing)
- Results typically in 7-14 days
Step 4: Frozen Embryo Transfer
- Only chromosomally normal embryos are selected for transfer
- Preparation of uterine lining with medication
- Thaw and transfer of the selected embryo
Who Should Consider PGT in the Philippines?
Strong Candidates Include:
- Advanced Maternal Age (35+): Chromosomal abnormality risk increases with age
- Recurrent Pregnancy Loss: 2 or more miscarriages
- Previous IVF Failures: Especially with good-quality embryos
- Known Genetic Carriers: For conditions common in Filipinos like:
- Beta-Thalassemia
- Spinal Muscular Atrophy
- Cystic Fibrosis (less common but tested)
- Severe Male Factor Infertility
- Family Balancing: For medical gender-related conditions
Benefits of PGT at Our Manila Clinic
1. Higher Pregnancy Rates Per Transfer
- By transferring only genetically normal embryos, implantation rates increase significantly
- Our data shows 65-70% pregnancy rates with PGT-tested embryos for women under 38
2. Reduced Miscarriage Risk
- 50-70% of early miscarriages are due to chromosomal abnormalities
- PGT reduces this risk by approximately 50%
3. Single Embryo Transfer Safety
- With confidence in embryo quality, we can transfer one embryo at a time
- Eliminates risks associated with multiple pregnancies
4. Shorter Time to Pregnancy
- Fewer failed transfers and miscarriages mean reaching your goal faster
Understanding PGT Results: What the Report Means
Your report will show:
- Euploid: Normal chromosome number – suitable for transfer
- Aneuploid: Abnormal chromosome number – not recommended for transfer
- Mosaic: Mix of normal and abnormal cells – requires genetic counseling
- Inconclusive: Need re-biopsy or cannot be diagnosed
Frequently Asked Questions About PGT
Q: Does PGT guarantee a healthy baby?
A: PGT significantly reduces genetic risks but doesn’t eliminate all potential issues. Follow-up prenatal testing is still recommended.
Q: What happens to abnormal embryos?
A: They remain cryopreserved. We provide detailed counseling on options.
Q: How many embryos do we need for PGT to be worthwhile?
A: Typically 3 or more blastocysts to ensure at least one normal embryo.
Is PGT Right for Your Journey?
During your consultation at Alpha Fertility Centre, our specialists will consider:
- Your medical history and age
- Previous pregnancy outcomes
- Genetic screening results
- Your specific concerns and goals
We use the latest time-lapse incubators and biopsy techniques to ensure the highest success rates for PGT in the Philippines.
Ready to explore if PGT can improve your IVF success? Schedule a genetic counseling consultation with our IVF specialists or talk to us to learn more about our advanced genetic testing options.
